The placenta invades the adjacent uterus and controls the maternal immune system, like a cancer invades surrounding organs and suppresses the local immune response. Intriguingly, placental and cancer cells are globally hypomethylated and share an epigenetic phenomenon that is not well understood – they fail to silence repetitive DNA sequences that are silenced in healthy somatic cells. In the placenta, hypomethylation of retrotransposons has facilitated the evolution of new genes essential for placental function. In cancer, hypomethylation is thought to contribute (...) to activation of oncogenes, genomic instability, and retrotransposon unsilencing; the latter, we postulate, is possibly the most important consequence. Activation of placental retrotransposon-derived genes in cancer underpins our hypothesis that hypomethylation of these genes drives cancer cell invasion. This alludes to an interesting paradox, that while placental retrotransposon-derived genes are essential for promoting early hominid life, the same genes promote disease-susceptibility and death through cancer. Placental and cancer cells fail to silence retrotransposons that are normally silenced in healthy tissues. This has created new genes that are essential for placental function, yet they are also expressed in cancer. We hypothesize that active retrotransposons are a double-edged sword, contributing both adaptive and deleterious functions to biology. (shrink)

In this paper I add credence to Linda Zagzebski's (1994) diagnosis of Gettier problems (and the current trend to abandon the standard analysis) by analyzing the nature of luck. It is widely accepted that the lesson to be learned from Gettier problems is that knowledge is incompatible with luck or at least a certain species thereof. As such, understanding the nature of luck is central to understanding the Gettier problem. Thanks by and large to Duncan Pritchard's seminal work, Epistemic Luck, (...) a great deal of literature has been developed recently concerning the nature of luck and anti-luck epistemology. The literature, however, has yet to explore the very intuitive idea that luck comes in degrees. I propose that once luck is recognized to admit degrees even the slightest non-zero degree (of the relevant sort) precludes knowledge. Connecting this to Zagzebski's thesis, I propose that a given theory of warrant must guarantee truth in order to avoid Gettier counterexamples (or subsequently deny that warrant bears any relationship to the truth whatsoever), simply because a sufficient standard analysis of knowledge cannot allow for knowledge that is even marginally lucky. (shrink)

This research addresses equity in geographic access to financial services. As financial products and services continue to become more accessible and affordable, many low‐ to moderate‐income Americans remain unbanked and underbanked, relying instead upon informal, alternative financial service providers, including check cashing outlets and payday lenders. While geographic access to affordable financial products and services assists in the successful asset building strategies of economically vulnerable households, concerns that access to financial services is uneven persist. This article uses geographic information systems (...) and spatial binary logistic regression analysis to test the hypothesis that sociodemographic characteristics and mortgage lending variables have a predictive relationship on the presence of financial deserts—census tracts where check cashing outlets are more prevalent than banks—in southeastern Pennsylvania. Results of comparison of means and regression analysis reveal that these tracts are associated with higher than average population density, lower levels of median household income, a higher proportion of Black and Latinx residents, and higher levels of mortgage application denial. This article contributes to the ongoing debate over the emergence of a two‐tiered or dual financial service delivery system, whereby financial products and services are bifurcated based on socioeconomic status and geography. (shrink)

In this chapter, we will explore the luck at issue in Gettier-styled counterexamples and the subsequent problem it poses to any viable reductive analysis of knowledge. In the 1st section, we will consider the specific species of luck that is at issue in Gettier counterexamples, then, in the next section, I will briefly sketch a diagnosis of the Gettier Problem and try to explain why the relevant species of luck has proven to be extremely difficult to avoid. And finally, I (...) will consider a prominent objection to the proposed diagnosis of the Problem. (shrink)

Ian Fraser assesses the human qualities of the three saints who are celebrated for their contribution to Christianity in Britain. He also examines some contemporary issues related to their struggle to live faith fully.

Luck permeates our lives, and this raises a number of pressing questions: What is luck? When we attribute luck to people, circumstances, or events, what are we attributing? Do we have any obligations to mitigate the harms done to people who are less fortunate? And to what extent is deserving praise or blame a ected by good or bad luck? Although acquiring a true belief by an uneducated guess involves a kind of luck that precludes knowledge, does all luck undermine (...) knowledge? And how accurate are our luck attributions anyway? The academic literature has seen growing, interdisciplinary interest in luck, and this volume brings together and explains the most important areas of this research. It consists of 39 newly commissioned chapters, written by an internationally acclaimed team of philosophers and psychologists, for a readership of students and researchers. Its coverage is divided into six sections: (i) The History of Luck, (ii) The Nature of Luck, (iii) Moral Luck, (iv) Epistemic Luck, (v) The Psychology of Luck, and (vi) Future Research. The chapters in these sections cover a wide range of topics, from the problem of moral luck, to anti-luck epistemology, to the relationship between luck attributions and cognitive biases, to meta-questions regarding the nature of luck itself, to a range of other theoretical and empirical questions currently being investigated by ethicists, epistemologists, and psychologists. By bringing this research together, the Handbook serves as both a touchstone for understanding the relevant issues and a first port of call for future philosophical and psychological research on luck. (shrink)

Two intellectual vices seem to always tempt us: arrogance and diffidence. Regarding the former, the world is permeated by dogmatism and table-thumping close-mindedness. From politics, to religion, to simple matters of taste, zealots and ideologues all too often define our disagreements, often making debate and dialogue completely intractable. But to the other extreme, given a world with so much pluralism and heated disagreement, intellectual apathy and a prevailing agnosticism can be simply all too alluring. So the need for intellectual humility, (...) open-mindedness, and a careful, humble commitment to the truth are apparent. In this book, Dr Church and Dr Samuelson explicate a robust and vibrant account of the philosophy and science of this most valuable virtue, and they highlight how it can be best applied and personally developed. (shrink)

If the history of the Gettier Problem has taught us anything, it is to be skeptical regarding purported solutions. Nevertheless, in “Manifest Failure: The Gettier Problem Solved” (2011), that is precisely what John Turri offers us. For nearly fifty years, epistemologists have been chasing a solution for the Gettier Problem but with little to no success. If Turri is right, if he has actually solved the Gettier Problem, then he has done something that is absolutely groundbreaking and really quite remarkable. (...) Regrettably, however, while Turri’s account is both intuitive and elegant—improving upon many seminal projects within contemporary epistemology—I argue in this paper that any success against Gettier counterexamples it affords is merely fleeting. Straightforwardly, this is done in two sections. In §1, I briefly sketch Turri’s proposed solution to the Gettier Problem. Then, in §2, I level a counterexample against it. Unfortunately for Turri and his solution, in this paper we will see history repeat itself. (shrink)

The character of the current controversy over geneticallymodified (GM) agriculture, typified by protesters' use of emotivesymbolism, has been largely inspired by the Green movement'snon-governmental organizations and political parties. This articleexplores the deeper philosophical and spiritual motivations of the Greenmovement, to inquire why it is implacably opposed to GM agriculture. TheGreen movement's anti-capitalism, exemplified by the hate-symbol statusof Monsanto as the company pioneering GM crops, is viewed within thewider context of alienation in the modern era. A complex of meanings isseen in (...) Frankenstein as the focal symbol of GM protests, includingperceptions of risk, fears of the remixing of living identities seen ingenetic engineering, and resentment at the spiritual nihilism of thereduction of life to the digital code of DNA. By contrast, RobertGoodin's Green Theory of Value, which postulates the deep psychologicalimportance of nature in locating the self in a meaningful context largerthan ourselves, can explain the power of the Green symbol of thethreatened environment, Gaia. The advent of GM agriculture seems toimply that capitalism and technology can now enframe nature itself,leaving a world devoid of natural myth or meaning, with no escape fromthe alienation and nihilism of modernity. The central question posed forprotagonists of the GM debate is whether their agenda is based on thesepowerful but mythical conceptions of the environment, or whetherpreservation of the real environment is their primary ethic. (shrink)

The project ‘Te Kore Rongo Hungaora’/‘Uncontainable Second Nature’ is predicated on a bridge between Māori and European cultures. Based on this view, works from art and science were re-contextualized as cultural texts symbolic of belief systems. The project was conceived and curated for exhibitions in Istanbul and Rio de Janeiro. Discipline was not viewed as fixed, but fluid in a transformational environment. Five themes were selected from within European and Māori world-views: cosmological context, all is energy, life emerged from water, (...) anthropic principle and integrated systems. The selected works addressed more than one of these thematic regions. While aspects of thinking might be shared across a cultural boundary, the agreement is only at the level of summary of view, rather than at the level of detail. This distinction is important in moving human thinking forward to an integrated condition particularly where negotiating hybridity is concerned. Certainly knowledge is advanced in a sense, and cultural bridging can be observed in practice at several New Zealand organizations such as the National Institute of Water and Atmospheric Research, the Institute of Geological and Nuclear Sciences and the Department of Conservation which all employ staff whose position entails observance and care of Māori perspectives on subjects under investigation and study. The connection between the work of Kaumatua (elder) Dr Te Huirangi Waikerepuru and Zoologist Mike Paulin in the exhibitions was semantic rather than computational. Here the function of metaphor in uniting what were previously considered divergent world-views becomes apparent. Myth is often reported as distinctive to a specific culture, however, considering interconnections ignites a more expansive view of culture and consciousness. (shrink)

This article argues that there has been a general misunderstanding of the nature of role relations in Confucian role ethics. Recasting constitutive role relations in light of Beauvoir's ethics of ambiguity will aid in developing Confucian role ethics as a contemporary vision of human flourishing that can internally accommodate the need for a feminist transformation.

David B. Wong’s 2006 monograph, Natural Moralities: A Defense of Pluralistic Relativism,1 presents and defends a sophisticated and nuanced form of moral relativism that has been in development since his 1984 work, Moral Relativity. The present volume, Moral Relativism and Chinese Philosophy, is a collection of six critical essays focused on Natural Moralities, which are followed by Wong’s responses to each of his critics. I see the greater contribution of this volume, when we consider the title’s conjuncts, to be the (...) discussion of moral relativism, so in this review I will leave aside the debates over how best to interpret various Chinese philosophers.In Natural Moralities, Wong draws... (shrink)

The paper explores the limitations and distortions of religious discussion on the Internet within the wider context of those ethical challenges posed by controversy and debate in cyberspace where “language that is no longer checked and verified by physical reality loses its very grounding”. In particular, it attempts to establish a series of critical connections between the emergence of polemical forms of ‘feuilletonism’ in the area of religious comment and the characteristic weightlessness of language which has become detached from the (...) body, despite the latter’s extension and intensification in the concrete social realisations found in specific faith communities. (shrink)

In this exploratory paper, I consider how intellectual humility and epistemic injustice might contribute to the failure of testimonial exchanges. In §1, I will briefly highlight four broad ways a testimonial exchange might fail. In §2, I will very briefly review the nature of epistemic injustice. In §3, I will explore how both epistemic injustice and intellectual humility can lead to failures in testimonial exchange, and I’ll conclude by suggesting how intellectual humility and epistemic injustice might be related.

Does intellectual humility preclude the possibility of religious dogmatism and firm religious commitments? Does intellectual humility require religious beliefs to be held with diffidence? What is intellectual humility anyway? There are two things I aim to do in this short article. First, I want to briefly sketch an account of intellectual humility. Second, drawing from such an account, I want to explore whether intellectual humility could be compatible with virtuous religious dogmatism.

This paper will be broken down into four sections. In §1, I try to assuage a worry that intellectual humility is not really an intellectual virtue. In §2, we will consider the two dominant accounts of intellectual humility in the philosophical literature—the low concern for status account the limitations-owing account—and I will argue that both accounts face serious worries. Then in §3, I will unpack my own view, the doxastic account of intellectual humility, as a viable alternative and potentially a (...) better starting place for thinking about this virtue. And I’ll conclude in §4 by trying to defend the doxastic account against some possible objections. (shrink)

While the evidential problem of evil has been enormously influential within the contemporary philosophical literature—William Rowe’s 1979 formulation in “The Problem of Evil and Some Varieties of Atheism” being the most seminal—no academic research has explored what cognitive mechanisms might underwrite the appearance of pointlessness in target examples of suffering. In this exploratory paper, we show that the perception of pointlessness in the target examples of suffering that underwrite Rowe’s seminal formulation of the problem of evil is contingent on the (...) absence of broader context. In other words, we show that when such suffering is presented alongside broader contextual information, the appearance of pointlessness, on average, significantly diminishes. In §1 we briefly elucidate Rowe’s formulation of the problem of evil and the thought experiment that motivates a key premise. In §2 and §3 respectively, we briefly explain our hypothesis regarding Rowe’s case and our methods for testing these hypotheses. In §4, we elucidate our results, and in §5 we explore some of the philosophical implications of our findings and gesture towards some areas for future research. Finally, in §6, we briefly connect our research to some of the established philosophical literature on suffering and narrative before concluding. (shrink)

The problem of evil is an ideal topic for experimental philosophy. Suffering--which is at the heart of most prominent formulations of the problem of evil--is a universal human experience and has been the topic of careful reflection for millennia. However, interpretations of suffering and how it bears on the existence of God are tremendously diverse and nuanced. We might immediately find ourselves wondering why (and how!) something so universal might be understood in so many different ways. Why does suffering push (...) some people toward atheism while pushing others toward deeper faith? What cultural, psychological, or sociological differences account for this diversity of responses? And, importantly, what light might this diversity of responses shed on the problem of evil and how it has been formulated by philosophers in recent years? The primary aim of this paper is to highlight how the tools and resources of experimental philosophy might be fruitfully applied to the problem of evil. In the first section, we review some recent work in this area and describe the current state of this emergent body of literature. In the second section, we review the broader and more recent theoretical developments on the problem of evil. Finally, in the final section, we outline some potential areas of future empirical research that we see as especially promising given those developments. (shrink)

In this short paper, I highlight two potential hurdles for teams of researchers conducting interdisciplinary research: “the translation problem” and the “academic isolation” problem. Along the way, I’ll note some ways those hurdles were overcome within the context of the “Science of Intellectual Humility” project.

The introduction to a special issue of Religious Studies on the theme of experimental philosophy of religion.

The primary aim of this paper is to highlight, at least in short, how the resources of experimental philosophy could be fruitfully applied to the evidential problem of evil. To do this, we will consider two of the most influential and archetypal formulations of the problem: William L. Rowe’s article, “The Problem of Evil and Some Varieties of Atheism” (1979). and Paul Draper’s article, “Pain and Pleasure: An Evidential Problem for Theists” (1989). We will consider the relevance of experimental philosophy (...) to Rowe’s 1979 argument in §1 and to Draper’s 1989 argument in §2. But in addition to exploring how the resources of experimental philosophy might apply to the problem of evil, it is also worth exploring what broader empirical factors might contribute to people having the intuitions that have—from someone’s affective state to someone’s need for closure. In §3, we want to very briefly elucidate a few areas where the psychology of philosophy might be productively explored in future empirical research. (shrink)

We critique two popular philosophical definitions of intellectual humility: the “low concern for status” and the “limitations-owning.” accounts. Based upon our analysis, we offer an alternative working definition of intellectual humility: the virtue of accurately tracking what one could non-culpably take to be the positive epistemic status of one’s own beliefs. We regard this view of intellectual humility both as a virtuous mean between intellectual arrogance and diffidence and as having advantages over other recent conceptions of intellectual humility. After defending (...) this view, we sketch remaining questions and issues that may bear upon the psychological treatment of intellectual humility such as whether evidence will help determine how this construct relates to general social humility on the one hand, and intellectual traits such as open-mindedness, curiosity, and honesty on the other. (shrink)

This book builds on established ecological models that can be applied to social systems, particularly the adaptive cycle. It links these ideas to key theoretical stances from across the educational literature to create an epistemological consilience across the divide between structuralist-poststructuralist educational research literatures. It is written with a consideration of the practical moves that can be undertaken within an institution to develop a healthier environment in which sustainable pedagogies can be nurtured. Kinchin argues that the ecological university may be (...) seen as a way to 'mend' the current system so institutions can justify the use of popular terms like sustainability, inclusivity and wellbeing in an ecologically authentic and demonstrable way. (shrink)